They are also used to treat attention-deficit hyperactivity disorder (ADHD), narcolepsy, and Parkinson’s disease.
NDRIs are a newer class of antidepressants and tend to have fewer side effects than other common antidepressant drugs.
What is the most important information I should know about NDRIs?
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How NDRIs Work
NDRIs work by inhibiting the reuptake ofnorepinephrineanddopaminein the brain.
Norepinephrine regulates alertness and concentration, while dopamine regulates mood.
When these chemical messengers malfunction, they can contribute tomood disorderssuch as depression and anxiety.
They do this by blocking the actions of norepinephrine and dopamine transporters.
Norepinephrine is involved in the body’sfight-or-flight response, while dopamine is associated with the reward system.
The most common brand name of bupropion available is Wellbutrin.
Its also available under other brand names like Zyban and Alpezin.
Wellbutrin is primarily used to treatmajor depressive disorder.
Its also commonly used off-label to treat ADHD.
Dexmethylphenidate
Dexmethylphenidateis typically used for the treatment of ADHD.
It is also sometimes used off-label to help treat certain forms of depression.
The brand name version of dexmethylphenidate is Focalin.
Its essential to know that Focalin can be habit-forming.
So, you shouldnt take it for longer than prescribed or take more quantities than your prescription advises.
Methylphenidate
Methylphenidateis a drug used to treat ADHD in adults and children.
You might recognize methylphenidate by other brand names like Concerta, Methylin, and Metadate.
Methylphenidate helps to increase the attention span and reduce symptoms of hyperactivity and impulsivity in people with this condition.
It is typically used alongside other treatment options, such asbehavior therapy, when used to treat ADHD.
It’s also possible to experiencesuicidal thoughtswhen taking these types of drugs.
If you are having suicidal thoughts, contact theNational Suicide Prevention Lifelineat988for support and assistance from a trained counselor.
If you or a loved one are in immediate danger, call 911.
For more mental health resources, see ourNational Helpline Database.
If you develop a dependency on NDRIs, your doctor may stop their use or reduce your dosage.
NDRI Interactions
Certain medications can interact with NDRIs.
Drug interactions can affect how well your medications work or lead to side effects.
Using an NDRI while takingmonoamine oxidase inhibitors(MAOIs) is strongly cautioned against.
In some cases, combining these two medications can causeserotonin syndrome,a potentially life-threatening condition.
Using antipsychotic medications with NDRIs could also increase your risk of seizures.
Antidepressant medications such as NDRIs can be an important part of your overall treatment plan.
Your doctor may recommend medication as well as other changes, such as psychotherapy and lifestyle modifications.
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