Having adequate levels of these neurotransmitters is important as it can affect mood.
If they are out of balance, this can also play a role inmental illnessdevelopment.
A 2013 study assessed the effects of taking L-methylfolate on depression.
Maskot / Getty Images
A 2021 review of six studies found similar results.
This variation leads to reduced conversion of folic acid to L-methylfolate.
So, these individuals are likely to benefit from L-methylfolate in addition to taking antidepressants.
Schizophrenia
Low folate levels are also associated with an increasedrisk of schizophrenia.
Folate helps break down the amino acid homocysteine.
If folate levels are low, this breakdown cannot effectively occur, leading to high homocysteine levels.
High homocysteine can cause neurodegeneration, which is a characteristic of schizophrenia.
A 2018 study involved 55 subjects with schizophrenia.
Some received L-methylfolate for 12 weeks and the rest received a placebo or sham treatment.
Those receiving L-methylfolate had improvement in theirschizophrenia symptomswhile there was no difference in the group receiving a placebo.
you might ask your provider for a comprehensive list of active and inactive ingredients to be sure.
Your dose may need to be adjusted during these times.
It’s important to not increase or reduce the dosage prescribed to you without first consulting your physician.
How to Take and Store Deplin
you could take Deplin with or without food.
However, it should be swallowed whole and not chewed or split into two.
If you miss a dose, take it as soon as you remember.
Store your medication in a dry place, at room temperature, and away from direct sunlight.
Avoid storing it in your bathroom as bathrooms can be humid and moist.
Deplin should be taken regularly for the most optimal benefits.
Warnings and Interactions for Deplin
Some people might experience an allergic reaction while using this drug.
Choudhury A, Sahu T, Ramanujam PL, et al.Neurochemicals, behaviours and psychiatric perspectives of neurological diseases.Neuropsychiatry.
2013;15(4):PCC.13m01520.
2019;29(5):386-391. doi:10.1089/cap.2019.0006
University of Michigan Medicine.L-methylfolate.
Wang D, Zhai JX, Liu DW.Serum folate levels in schizophrenia: A meta-analysis.Psychiatry Res.
2016;235:83-89. doi:10.1016/j.psychres.2015.11.045
Cleveland Clinic.Levomefolate tablets and capsules.
2019;31(1):4-16.
American Psychiatric Publishing, Inc.Medication information for parents and teachers: L-methylfolateDeplin.
Hardin A, Baldwin-Sayre C.L-methylfolate as a monotherapy for treatment-resistant depression: A case study.Integr Med (Encinitas).
2020;19(4):14-18.
