Maskot / Getty Images

What Is Amotivational Syndrome?

Amotivational syndrome is a psychiatric condition characterized by changes in a persons personality, emotions, and cognitive function.

A person with this condition will experience alack of concentrationand activeness, apathy, andpoor memory.

Man looking worried

Maskot / Getty Images

The condition was first observed in the 1960s among people who hada long history of cannabis use.

It has since been linked to the use of otherpsychoactive drugssuch asmethamphetaminesand some over-the-counter cough syrups.

Amotivational Syndrome Symptoms

The earliest signs of amotivational syndrome are signs ofapathy.

Dopamine is the “feel good” neurotransmitter and low levels are linked with feelings of apathy andanhedonia.

Serotonin is another neurotransmitter linked with mood.

An imbalance in the serotonergic system can wreak havoc on one’s sense of well-being.

Psychoactive substances are considered to be any drugs or substances that alter the way your brain works.

Examples

Marijuana- and SSRI-induced amotivational syndrome are the two most common types of the condition.

Other substances such as stimulants and solvents are also suspects in this syndrome.

Marijuana

Amotivational syndrome was first observed among people who use marijuana frequently.

However, the link between marijuana use and amotivational syndrome continues to be a source of controversy and debate.

In a 2018 study, researchers tested the link between marijuana use and amotivational syndrome in 505 college students.

They factored in age, gender, and race demographics.

They also included evaluations of the participants' personalities.

For example, researchers considered whether participants were using any other substances such astobacco and alcohol.

They concluded that marijuana is a risk factor for developing the syndrome.

Research does show that cannabis is the most commonly attributed cause of amotivational syndrome.

Amotivational syndrome is a potential side effect of using SSRIs that often goes unreported.

This comes off as dose-dependent, with higher doses producing more symptoms of apathy.

It is important to identify the root cause if possible.

The use ofantidepressants and psychotherapyis typically recommended for the treatment of the condition.

If you suspect it may be the side effect of substance abuse, try cutting back or quitting.

Are you taking SSRIs?

Maybe you oughta switch to a different anti-depressant.

Ozaki S, Wada K.Amotivational syndrome in organic solvent abusers.Nihon Yakurigaku Zasshi.

2010;7(10):14-18.

Luca R, Angelo, GIM, Matteo P, et al.Negative dimension in psychiatry.

Amotivational syndrome as a paradigm of negative symptoms in substance abuse.Rivista di Psichiatria.

1973;130(12):1319-1322.

1996;31(5):451-461.

2010;18(6):562-569. doi:10.1037/a0021964

Johns Hopkins Medicine.Is cough syrup an antidepressant?

2017;47(4):59-63.