It is a Schedule I substance in the U.S., meaning s there is not currently accepted medical use.
These substances affect the opioid receptors in the brain and body to produce pain relief.
Morphine and codeine are the two most common opiates.
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Some of these include heroin, oxycodone, andmethadone.
How Opiates Affect the Brain
Both humans and animals have opiate receptors in the brain.
These receptors act as action sites for different types of opiates, such as heroin and morphine.
Opiates and opioids bind to specific receptors in the brain, mimicking the effects of pain-relieving chemicals produced naturally.
These drugs bind to opiate receptors in the brain, spinal cord, and other locations in the body.
This blocks the perception of pain.
When this happens, people require higher doses to achieve the same effects.
They affect powerful reward systems in the brain.
Over time, the brain needs these substances to continue experiencing rewards and avoid withdrawal.
Some people can even become addicted when taking them exactly as prescribed.
Failing to take medications as directed or combining medications with other substances can increase this risk.
There are also individual differences in genetic vulnerability to opiate addiction.
The first step is to talk to your doctor about what actions will help you stop using opiates.
They may also prescribe a medication such as buprenorphine or methadone to prevent withdrawal symptoms.
Treatment for opiate and opioid addiction often involves psychotherapy, medication, and support groups.
In some cases, inpatient treatment or intensive inpatient therapy may be needed.
For more mental health resources, see ourNational Helpline Database.
National Institute on Drug Abuse.Opioids.
Department of Justice/Drug Enforcement Administration.Drug fact sheet.
RIDOH State Health Laboratories.The opioid epidemic: What labs have to do with it?
Drug Enforcement Administration.Controlled substances by controlled substances code number.
U.S. National Library of Medicine.Thebaine.
2020;87(1):44-53. doi:10.1016/j.biopsych.2019.05.023
National Institute on Drug Abuse.Introducing the human brain.
Drugs, Brain, and Behavior: The Science of Addiction.
U.S. Department of Labor.Risk factors for opioid misuse, addiction, and overdose.
Webster LR.Risk factors for opioid-use disorder and overdose.Anesth Analg.
2017;125(5):1741-1748. doi:10.1213/ANE.0000000000002496
Centers for Disease Control and Prevention.U.S.
opioid prescribing rate maps.
Centers for Disease Control and Prevention.Overdose death rates.
National Institute on Drug Abuse.Drug overdose death rates.
National Institute on Drug Abuse.Prescription opioid use is a risk factor for heroin use.
Kreek MJ, Reed B, Butelman ER.Current status of opioid addiction treatment and related preclinical research.Sci Adv.
2019;5(10):eaax9140.
2020;215:108213. doi:10.1016/j.drugalcdep.2020.108213
American Society of Addiction Medicine.Opioid addiction disease: 2016 facts and figures.
Volkow ND.What science tells us about opioid abuse and addiction.
National Institute on Drug Abuse.
