Wellbutrin (bupropion) is an antidepressant sometimes prescribed off-label forattention-deficit/hyperactivity disorder (ADHD).
In certain instances, people may be prescribed both a stimulant andWellbutrin for ADHD.
Keep reading to learn more about how Wellbutrin may help people manage some characteristics of ADHD.
Sturti / Getty Images
Also, find out more about the efficacy, potential side effects, and typical dosages in treating ADHD.
How Wellbutrin Works for ADHD
Wellbutrin is anorepinephrine and dopamine reuptake inhibitor (NDRI).
Wellbutrin does not influence serotonin, so it works differently than manyother types of antidepressants.
Effectiveness for ADHD
Studies of Wellbutrin’s effectiveness are ongoing but generally positive about ADHD.
One review of the research found that Wellbutrin showed potential benefits for treatingadult ADHD.
For this reason, many clinicians continue to prescribe Wellbutrin as an off-label treatment for ADHD.
It’s a common, legal practice.
How Long Does It Take to See Results?
Why Take Wellbutrin for ADHD?
Wellbutrin and Smoking Cessation
Wellbutrin andZybanare brand names for bupropion.
It does not contain nicotine, but some people who smoke report that it decreases their desire to smoke.
Swallow the tablet whole, without crushing or breaking it.
Generic versions are available and cost less than Wellbutrin.
Don’t stop taking Wellbutrin abruptly.
The sustained-release formulation is usually taken as a 150 mg dose once or twice daily.
The extended-release formulation is taken as a 300 mg dose once per day.
Wellbutrin is no exception.
If you are having suicidal thoughts, contact theNational Suicide Prevention Lifelineat988for support and assistance from a trained counselor.
If you or a loved one are in immediate danger, call 911.
For more mental health resources, see ourNational Helpline Database.
If you have a history of kidney or liver problems, your doctor may suggest taking a lower dose.
Older adults with reduced kidney function may also require lower doses.
This includes the smoking cessation medication Zyban and Contrave, a weight-loss medication containing bupropion and naltrexone.
Drinking alcohol while taking Wellbutrinincreases your risk for seizures and suicidal thoughts.
Other Treatments for ADHD
Wellbutrin is not the only treatment for ADHD.
ADHD traits are most often managed using medications, therapy, accommodations, and other forms of support.
Non-pharmaceutical approaches such as therapy can help, too.
As a norepinephrinedopamine reuptake inhibitor (NDRI), Wellbutrin is effective in combating fatigue.
For example, research has found that bupropion is effective in significantly reducing fatigue in people who have cancer.
Ng QX.A systematic review of the use of bupropion for attention-deficit/hyperactivity disorder in children and adolescents.J Child Adolesc Psychopharmacol.
2017;10(10):CD009504.
2014;52(9):675-80.
2014;52(9):675-680.
Food and Drug Administration (FDA).Zyban (bupropion hydrochloride) sustained-release tablets.
Berigan TR, Harazin JS.Bupropion-associated withdrawal symptoms: A case report.Prim Care Companion J Clin Psychiatry.
1999;1(2):50-51. doi:10.4088/pcc.v01n0205
Food and Drug Administration.Highlights of prescribing information: Wellbutrin.
2016;33:S545.
2019;17(4):537-541. doi:10.9758/cpn.2019.17.4.537
Bupropion.
In:Drugs and Lactation Database (LactMed).
National Library of Medicine (US); 2006.
WELLBUTRIN (bupropion hydrochloride) tablets.
National Alliance on Mental Illness.Bupropion (Wellbutrin).
2018;19(6):1547-1551. doi:10.22034/APJCP.2018.19.6.1547