Always check with your doctor before taking a nutritional supplement.
At a Glance
Chromium picolinate is a compound sold as a nutritional supplement.
Some studies suggest it may also help with depression, although more research is needed.
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Overview of Chromium Picolinate
Chromium is a mineral that can be found in two main states.
“The second is hexavalent or CR VI, which is found in industrial pollution and considered toxic.
A higher absorption rate means that more of the mineral gets into the bloodstream for use.
In this role, it provides a number of physical health benefits.
Some of the benefits of chromium are:
Chromium also helps convert glucose into energy.
In this capacity, it may provide positive effects oninsulin resistance, which is a precursor to diabetes.
Chromium Picolante for Depression
Some research has also connected chromium with mental health benefits.
Tryptophan is converted into a neurotransmitter calledserotonin.Serotonin is a neurotransmitter that is associated with mood and behavior.
Chromium might also help depression by inducing and enhancing the release of norepinephrine, another mood-regulatingneurotransmitter.
The activation of this receptor has been associated with an increased risk for depression.
It’s unclear how chromium picolinate works to decrease the activity in this receptor.
However, the effect is similar to that seen in people who’ve usedantidepressantsfor a long time.
Is Chromium Picolinate Effective for Depression?
The research looking at chromium for treating depression is very preliminary, and findings have been mixed.
Studies supporting its use are older, and there is a need for more current research.
So, it’s a long way from clear that chromium truly could be a viable treatment for depression.
For more mental health resources, see ourNational Helpline Database.
In some cases, chromium may cause an upset stomach.
In some cases, medications may impair or increase the absorption of chromium.
In other instances, chromium may interfere with or enhance the effects of medications.
Do not take chromium supplements if you are pregnant or breastfeeding.
Chromium Picolinate Dosage and Preparation
Chromium is widely available over the counter.
Chromium is also available by prescription as an injection.
How Much Should You Take?
Supplements often contain between 50 and 200mcg per dosage.
The suggested dosage for this injection is 10 to 15 mcg per day for adults.
Chromium Picolinate Dosage for Depression
There are no current chromium dosage recommendations for people who have depression.
How Much Is Too Much?
Always follow the dosage recommendations and talk to your healthcare provider about anypotential interactionsor concerns beforehand.
It’s rare to take in too much chromium, potentially because it has such low availability rates.
Although, high doses of any trace mineral can result in damage to the liver and kidney.
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