What Are Serotonin and Norepinephrine Reuptake Inhibitors?

Serotonin and norepinephrine reuptake inhibitors(SNRIs) are one class of antidepressant medications.

These antidepressants are frequently prescribed to treat mood disorders, such as major depressive disorder and depression inbipolar disorder.

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These messengers are responsible for directing information throughout the brain.

The neurotransmittersserotoninandnorepinephrineare thought to be particularly linked to the occurrence of panic disorder.

Both neurotransmitters play a role in regulating certain functions and emotions that can affect the onset of this condition.

Serotonin is connected to the regulation of mood and sleep.

Norepinephrine is responsible for how the person reacts to stress and anxiety and is associated with thefight-or-flight response.

SNRIs work to influence both serotonin and norepinephrine by preventing a persons brain cells from rapidly absorbing these neurotransmitters.

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Side Effects

It is possible to experience side effects when taking SNRIs.

Some of the most common side effects of SNRIs include:

These side effects should decrease over time.

Consult your doctor if side effects dont improve or worsen.

It is possible to experience a serious drug allergy from SNRIs.

If you are having suicidal thoughts, contact theNational Suicide Prevention Lifelineat988for support and assistance from a trained counselor.

If you or a loved one are in immediate danger, call 911.

For more mental health resources, see ourNational Helpline Database.

Drug Interactions

Certain medications should not be taken or should be used with caution along with SNRIs.

Keep your doctor up-to-date with any prescribed and over-the-counter medications you are taking.

Special Populations

SNRIs can be passed from mother to child during pregnancy or while nursing.

If you are pregnant or nursing, discuss the potential risks of taking SNRIs with your doctor.

Older adults are often more susceptible to experiencing the side effects of SNRIs.

If you are an older adult taking SNRIs, talk to your doctor about potential side effects.

Silverman, Harold M. (2010).The Pill Book.14th ed.

New York, NY: Bantam Books.