Treatment-Resistant Depression
Treatment-resistant depression describes depressive symptoms that continue even after the treatment should have started working.
So, if you’re beginning treatment for your depression, the process may involve some trial and error.
If you discover that various treatments are not working for you, you likely have treatment-resistant depression.
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However, researchers have pinpointed some risk factors that make someone more likely to experience TRD.
What Else Can Increase Your Risk of TRD?
They did not receive the proper treatment.
One study found that 34% of participants with TRD met the diagnostic criteria for ADHD, for example.
Chronic Depression vs. As a result, a long-term and holistic treatment approach is required.
Can Treatment-Resistant Depression Be Treated?
Yes, treatment-resistant depression can be treated.
TRD means you arent responding to first-line depression therapies like antidepressants.
Still, various treatment approaches are available, including medication, psychotherapy, and even lifestyle changes.
If youve run through multiple trials of antidepressants without success, that doesnt mean you depression is untreatable.
Is There Hope for Treatment-Resistant Depression?
After multiple trials of different treatments with no success, its easy to feel hopeless and incurable.
But there is still a path forward, even if you havent had any luck with antidepressants.
The biggest predictor of a positive outcome for patients with TRD was having social support.
So if you have friends or family that you feel safe reaching out to, do that.
Among those,ketaminemay be the most promising.
The improvements lasted an average of 5 to 7 days.
Neuroscience & Biobehavioral Reviews.
Doi:10.1016/j.neubiorev.2017.08.019
Ionescu DF, Rosenbaum JF, Alpert JE.Pharmacological approaches to the challenge of treatment-resistant depression.
Dialogues in Clinical Neuroscience.
2015;17(2):111-126.
Doi:10.31887/DCNS.2015.17.2/dionescu
Al-harbi.Treatment-resistant depression: therapeutic trends, challenges, and future directions.
Published online May 2012:369.
2010;127(1-3):10-18.
Doi: 0.1016/j.jad.2010.06.036
Hamish McAllister-Williams R. Defining treatment-resistant depression, difficult-to-treat depression, and staging treatment intensity.
Published online January 1, 2022:1-12.
2012;201(5):369-375.
Doi:10.1192/bjp.bp.111.102665
Voineskos D, Daskalakis ZJ, Blumberger DM.Management of treatment-resistant depression: challenges and strategies.