If you stop taking your antidepressant suddenly, you may experience withdrawal symptoms known as SSRI discontinuation syndrome.
“SSRI withdrawal symptoms are not uncommon.
They can start when people abruptly stop taking antidepressants.
Verywell / Emily Roberts
What Is SSRI Discontinuation Syndrome?
The drugs help normalize brain function in people with certain mood disorders by increasing the amount ofserotoninin the brain.
This term describes how long an active drug molecule stays in the bloodstream before being expelled from the body.
Most SSRIs have short half-lives.
When this happens, the person taking them may experience disconcerting or even profound withdrawal symptoms.
Changes in the Brain
Drug half-life is only part of the reason for SSRI discontinuation syndrome symptoms.
When used over a period of time, SSRIs can cause changes in the brain that affect serotonin receptors.
It’s a physiological balancing act meant to prevent the overstimulation of brain cells.
The body will typically correct this, but there will be a period of adjustment until the system normalizes.
Recap
Many SSRIs have a relatively short half-life, meaning they leave the body quite quickly.
When antidepressant levels drop suddenly, it may lead to symptoms of withdrawal.
While these symptoms can be uncomfortable, they are rarely severe.
Most people only experience mild to moderate forms of SSRI discontinuation syndrome.
If you or a loved one are in immediate danger, call 911.
For more mental health resources, see ourNational Helpline Database.
Taking your medication at the same time each day can help minimize the risk of experiencing withdrawal symptoms.
Don’t take a double dose to make up for your missed dose.
Otherwise, discontinuation symptoms last for about one to two weeks.
After six to eight months of treatment, you may need to taper off over six to eight weeks.
Your tapering schedule will depend on the medication you are taking and how long you have been taking it.
Your doctor may also adjust your schedule as needed depending on your symptoms.
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