Serotonin is a neurotransmitterthat plays an important role in regulating various body functions and feelings.
There are several different substances, including medications and supplements, that canincrease serotonin levelsin the brain.
Here’s what you gotta know.
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This list is not meant to be all-inclusive.
If you develop symptoms of serotonin syndrome, seek immediate medical attention.
When serotonin reuptake is inhibited, more serotonin is available in the brain.
Recap
SSRIs are antidepressant medications that work by blocking the reuptake of the neurotransmitter serotonin.
This results in increased serotonin levels in the brain, which can improve mood and reduce anxiety.
Norepinephrine is a neurotransmitter that influences sleep and alertness.
It is believed to be correlated to thefight-or-flight stress response.
They act on serotonin receptors in the brain, thereby affecting serotonin levels.
TCAs are also used to treat certain pain syndromes and nocturnal enuresis (bedwetting).
It is believed that TCAs function by increasing levels of norepinephrine and serotonin in the brain.
They are effective for the treatment of major depressive disorder, panic disorder, and other anxiety disorders.
Other Psychiatric Medications
There are also other psychiatric medications that can influence serotonin levels in the body.
Analgesics (Painkillers)
A number ofanalgesic drugscan also affect serotonin levels in the body.
This can potentially lead to drug interactions when people are taking other medications such as SSRIs or MAOIs.
Ginseng
Ginseng is a root that is often used as an herbal supplement.
Purported benefits include improved immunity, energy, and cognition.
Ginseng acts on serotonin and other transmitters and also affects hormones, receptors, and signaling molecules.
Research suggests that ginseng is associated with interactions with somepsychotropic medications, including SSRI and SNRI antidepressants.
Amphetamines
Amphetamine stimulantsare often prescribed to treat attention-deficit hyperactivity disorder (ADHD).
These medications can also increase serotonin levels.
Cocaine
Cocaine blocks the reuptake of serotonin.
LSD
Lysergic acid diethylamide (LSD)is a hallucinogenic drug that affects thinking and moods.
These effects are the result of the impact of the drug on serotonin.
The drug binds to certain receptors in the brain and changes how the brain responds to serotonin.
Combining antidepressant medications and LSD has the potential to produce unwanted effects associated with serotonin toxicity.
Potential Serotonin Drug Interactions
Taking one or more medications that impact serotonin levels can be potentially dangerous.
Healthcare professionals can help identify if serotonin syndrome exists and, if it does, prescribe the necessary treatment.
2017;59(Suppl 1):S34-S50.
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2022;14(3):e22805.
