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Unfortunately, semaglutide has not yet been thoroughly tested in people with depression.
Neither has tirzepatide (Mounjaro, Zepbound), another blockbuster injectable medication in the same family.
But there has been some preliminary research that hints at positive effects.
Heres what we know so far about Ozempic and depression.
Ozempic and Depression: What Does the Research Say?
But there are some reports that hint at how the drug may affect mental health in general.
These early findings suggest GLP-1 drugs like Ozempic could even play a role in treating depression in the future.
But more studies are needed before that happens.
Both Wegovy and Zepbound still carry warnings on their FDA labels about the risk of suicidal behavior and ideation.
(The labels for Ozempic and Mounjaro do not.)
Should People Be Screened for Depression Before Starting Ozempic?
More research is still needed, says Volkow.
He lives in Denver, where he enjoys spending time with family, and playing tennis.
Shelby House, RN, BSN, has been a registered nurse for almost 10 years.
She received her bachelor’s degree in nursing from Maryville University in Missouri.
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