Verywell / Madelyn Goodnight

The quest to find the bestantidepressant medicationcan feel very “hit or miss.”

They often consider several factors, such as the symptoms experienced and whether any other health conditions are present.

Patient Symptoms

Some antidepressants provide benefits for multiple symptoms.

Mind Doc Guide

Get our printable guide to help you ask the right questions at your next doctor’s appointment.

So, if other symptoms are present, a physician may lean more toward a certain medication.

Other Medications Being Taken

Taking an antidepressant with certain other medications can lead todrug interactions.

This includes not only prescription drugs but also over-the-counter medicines, vitamins, and dietary supplements.

Family History

Not everyone responds to depression medication the same way.

Antidepressant Cost

Some newer antidepressants don’t yet have a generic form available.

So, they may be costly.

Some physicians are more willing to consider prescribing off-label medications than others.

Get our printable guide to help you ask the right questions at your next doctor’s appointment.

Sexual Side Effects

One of the classic symptoms of depression is a loss of sex drive.

Rather ironically, many of the medications used to treat depression can also potentially havesexual side effects.

Certain antidepressant medications have fewer sexual side effects than others.

Weight Gain

Weight gainis another commonly complained about side effect of antidepressants.

An increase in weight can be uncomfortable physically, also affecting one’s confidence and self-esteem.

Two people can respond to the same medication differently.

Overcoming Antidepressant Barriers

Discussing thepros and cons of antidepressantscan be helpful in overcoming the side effect barrier.

It can also help the patient understand more of the potential effects of this form of depression treatment.

Side Effects Aren’t Always Bad

Some antidepressant side effects can actually be helpful.

Conversely, a patient who is underweight can benefit from a drug that causes appetite to increase.

Again, it is important to remember that every person is different.

Click below to listen now.

The Importance of Open Communication

Finding the best antidepressant can take some trial and error.

It enables the patient and physician to work together as a team to find the bestdepression treatmentpossible.

National Institute of Mental Health.Mental health medications.

2016;85(5):270-88. doi:10.1159/000447034

Mental Health America.Co-occurring disorders and depression.

2020;10(12):992. doi:10.3390/brainsci10120992

Obata H.Analgesic mechanisms of antidepressants for neuropathic pain.Int J Mol Sci.

2018;14:567-589. doi:10.2147/NDT.S157708

National Library of Medicine.Antidepressants.

2022;19(24):16788. doi:10.3390/ijerph192416788

Nosengo N.Can you teach old drugs new tricks?Nature.