5-HTP Uses and Tips
If you’re considering the use of 5-HTP supplements, talk with your doctor first.
Self-treating a condition and avoiding or delaying standard care may have serious consequences.
5-HTP is a substance that is sometimes used as a supplement.
âVerywell / Cindy Chung
This article discusses what 5-HTP is, how it is used, and research on its potential effects.
It also covers some of the potential side effects and drug interactions that may occur.
What Is 5-Hydroxytryptophan?
5-Hydroxytryptophan (5-HTP) is a compound produced in the body from the amino acid tryptophan.
It is a precursor to the neurotransmitterserotoninand the hormone melatonin.
5-HTP is manufactured from the seeds of an African plant,Griffonia simplicifolia.
Serotoninis a jot down of neurotransmitter that carries signals between nerve cells in the brain.
It helps to regulate a variety of functions in the body, including attention, behavior, and mood.
By increasing serotonin levels in the brain, mood can often improve.
Here’s a look at some of the research studies so far.
The 5-HTP was found to be as effective as the antidepressant, with fewerside effects.
Potentially dangerous drug interactions may occur.
Insomnia
Serotonin is converted into melatonin, a hormone needed to regulate sleep-wake cycles.
Because 5-HTP is thought to increase serotonin levels, it may increase melatonin and help normalize sleep patterns.
A 2021 clinical trial found that supplementation with 5-HTP improved sleep latency for eight weeks among older adults.
Possible Side Effects
While side effects can occur, they are often mild.
Potential side effects of 5-HTP include:
One older study found that such side effects are dose-dependent.
In other words, they are worse the more of the supplement you take.
Rarely, an allergic reaction to the supplement may occur.
A severe allergic reaction may result in anaphylaxis.
If you experience any of these symptoms, seek medical attention immediately.
Peak x had been previously associated with the supplement tryptophan, which is made into 5-HTP in the body.
Some reports suggest that purity may be a potential problem for 5-HTP as well.
No cases of EMS resulting from 5-HTP use have been reported, however.
Contraindications
Individuals who have high blood pressure.
liver disease or diabetes should consult a healthcare professional before taking 5-HTP.
If you or someone you know experiences such symptoms, go to the emergency room or call 911 immediately.
Dosage and Preparation
There is not enough scientific data to provide a recommended dose of 5-HTP.
However, for depression, doses of 150-800 mg daily taken for 2-6 weeks have been described.
The appropriate dose for you may depend on factors including your age, gender, and medical history.
Speak to your healthcare provider to get personalized advice.
Be careful not to confuse 5-HTP with 5-hydroxytryptamine (5-HT), the chemical name for the neurotransmitter serotonin.
Always exercise caution when buying this or any supplement.
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